Endocrine Abstracts

HPA axis that plays important controlling and modulating functions in organism is also linked with insulin resistance and weight control. The number of evidences linking cortisol secretion with obesity and other metabolic complication increase, but still there is a lack of definitive results. Therefore the aim of our study was to compare adrenal function parameters between high and normal insulin resistant overweight and obese women. This retrospective analysis was performed o...

Introduction: Vitamin D, known mainly as a calcium-phosphorus homeostasis regulator, turned out to play also a significant role in the immune system modulation. Vitamin D deficiency has been reported in some autoimmune disorders. It is also suspected that polymorphisms of vitamin D-related genes comprise a risk factor for different autoimmune diseases. Therefore the aim of our study was to assess vitamin D receptor (VDR) gene FokI polymorphism in thyroid associated orbitopathy...

Introduction: Vitamin D, primarily known for its role in calcium–phosphorus homeostasis, is also a significant immunomodulatory factor. Vitamin D deficiency has been reported in some autoimmune disorders. Recently, vitamin D level in autoimmune thyroiditis (Hashimoto’s thyroiditis (HT)) has become the subject of researchers’ interest.Objectives: This study aims to assess vitamin 25-OH-D3 levels in HT patients in comparison to a control gro...

Thyrotropinoma is a very rare cause of hyperthyroidism. In October 2014 a 41-year-old male patient was examined for anaemia and diarrhoea. Abdomen CT scan, gastroscopy, colonoscopy and parasite tests did not reveal any abnormalities. The patient had lost 18 kg 7 years ago and his weight had been stable since then (BMI 21.3 kg/m2). The laboratory tests revealed high TSH, normal fT4 and low cortisol level. The patient referred to our department presented wi...

Introduction: Vitamin D is postulated to play a significant role in the immune system modulation and its deficiency has been reported in some autoimmune disorders. Polymorphisms of different vitamin D-related genes, among them vitamin D receptor gene (VDR), could either be a risk factor for autoimmune diseases. Therefore the aim of the study was to assess the association between VDR Cdx2 (rs11568820) polymorphism and autoimmune thyroid disease (AITD) among th...

Purpose: The aim of this study was to evaluate the association between the serum vitamin D level and changes in the titers of the anti-TSH receptor (TSHR), antithyroglobulin (Tg), and antiperoxidase (TPO) autoantibodies (Abs) in smoking cigarette Graves’ disease (GD) patients, with and without the vitamin D supplementation.Methods: The study was performed from January 2015 to December 2016. It consisted of 136 patients. The intensity of nicotinism w...